![]() Once your transfer is complete, you can withdraw local currency at an ATM. If you have a bank account in another country, you can also use an app like Wise to transfer money to yourself for a fee of a few dollars per transaction. If you must use cash, make an international withdrawal from an ATM. Instead, use a debit or credit card with zero foreign transaction fees and select local currency at the register (if you’re given the option). If you plan to exchange money for personal use, expert travelers will tell you to skip the currency exchange kiosk at the airport-they charge some of the highest fees and often have the worst exchange rates. It’s not as simple as trading one American dollar for its equivalent in Mexican pesos-the current value of each form of currency on the fluctuating foreign exchange market must also be considered. ![]() In addition, the value of your currency on the foreign exchange market can influence the value of your money once it’s converted to a new currency. Currency exchange companies make money by charging fees for the convenience of converting your cash. Via CurrencyFair's Website Live Exchange Rates How Does Currency Exchange Work?Īt a currency exchange, you can convert your cash into money you can use in a different country or region.Ĭurrency exchanges are businesses that trade various currencies. Keep in mind that the conversion provided here doesn’t consider any fees charged by the institution completing the exchange, whether it’s a bank, digital app or travel kiosk. Since this value can fluctuate due to various economic conditions, it’s important to know the current exchange rate before converting your money. Our currency conversion calculator uses the current exchange rate to determine how much your money is worth in a different currency. Related: International Money Transfer: 5 Best Ways To Send Money How Does a Currency Conversion Calculator Work? However, the rate you see here may not be the same rate that a bank or other financial institution offers you. We pull new rates every 5 minutes to ensure that the conversion you see is accurate and up to date. ![]() It also calculates the conversion value of various cryptocurrencies, such as Bitcoin ( USD to BTC) and Dogecoin ( USD to DOGE).Īll you have to do is input the amount, your starting currency and your ending currency to get an estimate based on current rates.ĭisclaimer: Our currency calculator uses Open Exchange API to gather current exchange rates. Among the currencies available, our calculator converts Mexican pesos, Indian rupees, Russian rubles, Jamaican dollars, and Ghanaian cedi. Our currency conversion calculator converts more than 200 currencies, and the rates are updated every five minutes.
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![]() Managing Allowance and Choresĭo you want to give your child a regular allowance? What about offering money in exchange for household chores and tasks? ![]() However, regardless of how old your children are or how long they’ve been learning about finances, there are a few specific areas of focus to consider when browsing apps. ![]() The financial app(s) you choose will vary depending on your child’s age and experience with money. (Personal Capital is now Empower) Key Lessons Now, if you’re considering a money app for your child, teen, or young adult, below are a few of our favorites. It’s free and has a ton of features to help you get your financial life in order. One of our favorite tools for adults to use to track their finances is Empower. These apps allow parents to pay their children for chores or allowance, track their spending, teach them about saving and budgeting, and even guide them into their first investments. Parents today have the opportunity to do so much more for their kids’ future, and they have the incredible tools - like money apps and platforms to help them do it. We didn’t have much financial education in school, either, with only a few days dedicated to things like writing a check and calculating interest. Unfortunately, most of these were learned by watching my parents make bad decisions that I was determined not to repeat. I grew up learning many financial lessons from my parents. This content has not been provided by, reviewed, approved or endorsed by any advertiser, unless otherwise noted below. We may receive compensation from the providers of some products mentioned in this article. ![]() Additionally, docking studies suggest the phenyl side groups of Tyr407 and Tyr444 (for MAO-A) or Tyr398 and Tyr435 (for MAO-B) play an important role in the interaction of the enzyme with 1,4-NQ scaffold through forces of dispersion as verified for menadione, TMN and 1,4-NQ. Fluorescence and molecular modeling data indicated that these inhibitors interact with the flavin moiety at the active site of the enzyme. Contrasting with TMN and 1,4-NQ, menadione exhibited a 60-fold selectivity for MAO-B (K(i)=0.4 μM) in comparison with MAO-A (K(i)=26 μM), which makes it as selective as rasagiline. ![]() ![]() Herein we show that MAO-B was inhibited competitively by 1,4-NQ (K(i)=1.4 μM) whereas MAO-A was inhibited by non-competitive mechanism (K(i)=7.7 μM). Menadione (2-methyl-1,4-naphthoquinone) is a multitarget drug that acts as a precursor of vitamin K and an inducer of mitochondrial permeability transition. Combining molecular modeling tools and biochemical assays we evaluate the kinetic and molecular details of the inhibition of human MAO by 1,4-NQ, comparing it with TMN and menadione. The discovery of 2,3,6-trimethyl-1,4-naphthoquinone (TMN) as a nonselective and reversible inhibitor of MAO, has suggested 1,4-naphthoquinone (1,4-NQ) as a potential scaffold for designing new MAO inhibitors. Monoamine oxidase ( MAO) catalyzes the oxidative deamination of biogenic and exogenous amines and its inhibitors have therapeutic value for several conditions including affective disorders, stroke, neurodegenerative diseases and aging. Molecular insights into human monoamine oxidase ( MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO.Ĭoelho Cerqueira, Eduardo Netz, Paulo Augusto Diniz, Cristiane Petry do Canto, Vanessa Follmer, Cristian The slightly different binding pose of 18 into the MAO-B active site seems to be forced by a bulkier Tyr residue, which replaces a smaller Ile residue present in MAO-A. In contrast, compound 7 places its phenyl ring into an aromatic cage of the MAO-B binding pocket, where it forms charge-transfer interactions. This H-bond is absent in the 7/ MAO-A complex. Compound 18 forms an H-bond with Gln215 through its protonated amino group into the MAO-A binding site. Docking and molecular dynamics simulations gave structural insights into the MAO-A and MAO-B selectivity. N-Methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine (7) and N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine (18) were the most selective MAO-B (7, SI = 0.0057) and MAO-A (18, SI = 12500) inhibitors, respectively. La Regina, Giuseppe Silvestri, Romano Artico, Marino Lavecchia, Antonio Novellino, Ettore Befani, Olivia Turini, Paola Agostinelli, EnzoĪ series of new pyrrole derivatives have been synthesized and evaluated for their monoamine oxidase ( MAO) A and B inhibitory activity and selectivity. New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. Thus has a dual function for both therapy and diagnosis. NMI can also be used as a non-invasive imaging tool. In conclusion, we have identified MAO A inhibitors as potential novel stand-alone drugs or as combination therapy with low dose TMZ for drug-resistant gliomas. Immunocytochemistry studies showed that the MAO A inhibitor reduced proliferation, microvessel density and invasion, and increased macrophage infiltration. NMI was localized specifically to the tumor. Using the intracranial TMZ-resistant glioma model, clorgyline or NMI alone or in combination with low-dose TMZ reduced tumor growth and increased animal survival. MAO A inhibitors, clorgyline or the near-infrared-dye MHI-148 conjugated to clorgyline (NMI), were cytotoxic for glioma and decreased invasion in vitro. This study shows that MAO A expression is increased in human glioma tissues and cell lines. Monoamine Oxidase A ( MAO A) oxidizes monoamine neurotransmitters resulting in reactive oxygen species which cause cancer. Tumors usually become resistant to TMZ and recur no effective therapy is then available. Glioblastoma (GBM) is an aggressive brain tumor which is currently treated with temozolomide (TMZ). Vaikari, Vijaya Pooja Kota, Rajesh Chen, Kevin Yeh, Tzu-Shao Jhaveri, Niyati Groshen, Susan L. Monoamine oxidase A ( MAO A) inhibitors decrease glioma progression Kids artwork and school work! Scan it.Check online to find your local drop-off location. You got a phone, but you don’t usually need to keep the box to keep the warranty. Empty boxes for appliances and products.Old magazines can be donated to your local doctor’s office.Unless you loved it and want to read it again, why keep it? Unread books- start a Little Free Library in your neighborhood!.Take a photo of something if you think you’ll need the info later. ![]() Do you really need 12 decorative pillows?.The junk at the bottom of your junk drawer.Broken toys equal unplayed with toys! Clutter also discourages kids from playing with toys, because it can be overwhelming!.Things To Throw Away: What to Get Rid of Everywhere Else Around the House Old underwear! Did you know that you should replace your underwear at least yearly?Ĥ.Clothes that are stained, torn or otherwise damaged.Whether they are too big or too small, you don’t need them! Keeping a few for dusting and cleaning purposes is fine if you actually use them. Give yourself a deadline, like if it has been waiting for more than a month, throw it out. Any clothing that you have waiting to be altered or fixed.Perfume and cologne that is more than 2 years old.Old running shoes- if they have an odor or have lost their shape, then it’s time for new ones.Things To Throw Away: What to Throw Out In the Bedroom The raggedy towels and washcloths no one in the house uses anymore.ģ.Your toothbrush, needs to be replaced regularly, especially after a cold.Old medications – bring them to your pharmacy or fire department for proper disposal.Leftover lotion and shampoo living at the bottom of the bottle.That’s how many months it stays fresh from opening. Check the little open bottle with a number printed on it. Any broken or expired beauty products.Old Liquid Makeup- the general rule of thumb here is to toss liquid makeup after 12 months, though things like mascara and eyeliner should be tossed after just 3 months.Things to Throw Away: What to Scrap In the Bathroom Look for duplicates and eliminate – you know you have an extra casserole dish you keep saying you’ll use someday!Ģ.Unmatched food storage containers and lids.Old and expired condiments in the back of the fridge.Donate that bag of beans or can of tuna you know you’re never going to use.Kitchen gadgets that you never reach for.Any chipped dishes or scratched plastic containers (chips and scratches harbor bacteria).Just get rid of those dusty chocolate bunnies! Chocolate can absorb smells anyway, it probably doesn’t even taste like chocolate anymore. Does anyone really need 400 of those? You can take them to a grocery store to be recycled. Things to Throw Away: What to Discard In the Kitchen Turn on some music or a podcast, grab some trash bags or bins, and label them things like, keep, sell, donate, trash, and recycle. So pick one area to start attacking to create more usable space. ![]() Marie Kondo might not be your cup of tea, but we could all use a little less mess in our homes. ![]() Tricks to Clean Up the Clutter from Around the Houseĭo you have a “catch-all” drawer or spot in every room? I think we all might have one, and maybe you don’t mind the mess, or perhaps you just don’t vibe with minimalism. Read through and find out what to toss and how to get started getting rid of the mess. Is your house cluttered? Sometimes the easiest solution is also the hardest – deciding what things to throw away, donate, or repurpose. ![]() Good for movies and probably gaming, do not own xbox console, and music. Once you buy dolby and/or dts, any earphone and headphone has dolby and dts audio, so pulse 3d and this both benefits from using them. So if you either one of them no need to buy both unless you want to use on their particular consoles they are meant for, on pc and mobile, both are equally good. Tested along side pulse 3d, better than Sennheiser hd 599 and overall it is about as good as pulse 3d, which is also very good but this has tiny bit better bass. These wireless gaming #Microsoft headsets set a new standard at the money. Since this is from Microsoft, it works really well with Teams calls and Windows laptop Only issue is when used for long hours, it gets sweaty around the earpads. Mic quality is really good, and best part is one can control the ambient noise using the software.ĭedicated hw button to mute and unmute mic.īattery is decent and worked for entire office hrs and some extra music hours. Sound is rich, also the option to customize the sound, control the base which is boomy but can be tapped down. Pairing is absolutely simple, hardly took 1 min to pair. Quality of these headphones feels premium, both the cushions and headbands are comfortable. Since the purpose was primarily Office calls over teams didn't want to go extravagant for headphone budget but also didn't want compromise in both sound/mic quality or build quality. Other than that, it’s really worth the price and changes the whole experience of gaming.įor sometime I have been looking for a wireless headphone as the wired headphone makes it impossible to stretch in those long never ending office calls. I am sure there must be a settings to switch it off. It gets annoying when you want to use it with any other device. I would not really call it a con but if you are in the same room where your Xbox is kept and if you turn on your headset, it will start the console as well. The volume and mic comes with easy to control dials on both ear cups.ġ. Looks - The looks are minimalistic and matches well with my series X. The Dolby Atmos app cost around 824/- INR one time pay but it’s worth it.ĥ. I found Dolby Atmos overall better than window Sonic. Dolby Atmos - it supports both Dolby Atmos and Window Sonic. Sound - with the default EQ settings it’s not the best but you can tweak it according to your liking and it becomes really good. Battery life - lasted 12 hours for me with single charge.ģ. Light weight and fits well - The polyurethane leather-covered pads are comfortable and deliver good noise isolation.Ģ. This is a great gaming headset for the price.ġ. Jess, Ph.D.), author, international speaker and PlayboyTV’s sexologist, offers an alternative to the cowgirl in her book The New Sex Bible, “If she doesn’t like the sensation of deep penetration, but he desires more stimulation against the base of his shaft, she can reach backwards with a warm, wet hand to grasp the lower half of his shaft. It helps to have had an orgasm already and be highly aroused.” Remember to go at an easy pace and stay relaxed. She explains, “This position will allow you to control the pace and depth that his penis goes inside of you. Pro tip: Make sure your bottom partner does not begin to thrust until you’re good and ready.Ĭertified Master Sex Expert and Educator, Sex Coach and “So Tight” Sensual Fitness Personal Trainer Nikki Ransom endorses the cowgirl position for anal newbies. ![]() In the traditional cowgirl position, your partner lies down while you mount on top - yeehaw! As the partner on top, you can ease into anal penetration by moving up or down as needed. Cowgirl (or cowboy) Image: SheKnows Design We checked in with some experts and asked them to take the mystery out of anal sex for beginners, and they schooled us on some positions that can help ease you into your first time to actually make it an enjoyable experience.Īrm yourself with these tips and a lot of lube, and you’re on your way to one kick-ass time. ![]() After all, some studies have found that mutual satisfaction was high across the gender orgasm gap in a sexual encounters that included anal, as FiveThirtyEight’s Mona Chalabi wrote in 2015: “100 percent of men and 94 percent of women say they orgasmed during encounters in which they received anal sex.” This could be because anal is something that requires a bit more foreplay and preparation to execute well or that the people who are having anal sex are maybe a bit more concerned with getting their partner off. But our greatest fears often lie in anticipation, and once you give anal a go, you might just find that you’ve been missing out on something that can actually be really hot and satisfying. ![]() Cooling Cover: Wrapping the three layers of foam is a removable, quilted polyethylene cover.Gel memory foam: A top layer of 3″ gel memory foam.Soft Support Foam: The proprietary material is a 2″ layer of memory foam that acts as a transition layer from the support foam below.Standard Foam Base Support : As the name implies, this 7″ layer serves as the bed’s foundation.Take an inside look at the construction of Nectar mattress. The Nectar mattress is available as a 12″ thick all-foam bed with three layers or as a 12″ hybrid model with individually wrapped springs. The foam responds to touch and returns to its original state when the weight is released. You won’t get that stuck-in-the-mud feeling when you sleep on it. When you lay down on the bed, you don’t immediately sink. However, it’s a different memory foam feel than other beds. ![]() When you lay down on it, the bed slowly contours to your body. With the three layers of memory foam, the Nectar mattress has a distinct, dense memory foam feel that traditional memory foam is known for. Pretty much anyone can sleep on a medium-firm mattress, so Nectar is a pretty versatile mattress. We think the mattress provides a comfy compromise between pressure-relieving and supportive. Since Nectar has a traditional memory foam feel, it’s difficult to grade the bed’s firmness, but we’d say it’s around a medium-firm on the firmness scale. While firmness refers to how soft or hard a bed’s surface is, the feel refers to the way you perceive the mattress while laying on top of all the bed’s materials. The feel of a mattress is not the same as firmness. For this review, we’re going to focus on the flagship original Nectar mattress. Nectar offers multiple mattresses for you to choose from.It’s comfortable, suitable for all sleeper types (especially for back and stomach sleepers) and maybe the most appealing thing of all, affordable. Overall, Nectar is a popular online bed because it has just about everything someone would want in a memory foam mattress.The Nectar mattress has a dense memory foam feel that memory foam fans know and love (with a price tag you might love even more).Here’s what you need to know about the Nectar bed: ![]() If that sounds like the bed you’re looking for, you might like what we have to say in our Nectar Mattress review. We like the Nectar bed for its nestling, pressure-relieving memory foam feel that slowly conforms to the curves of your body. Nectar is owned by Resident, aka the parent company that owns DreamCloud and Awara. It has established itself as one of the most popular memory foam bed-in-a-box brands, though you can buy a Nectar mattress in stores across the country. ![]() The Nectar Original is one of the best mattresses in the market. For more information, please see How we make money. All information is presented without any warranty or guarantee to you. And the advertised offers may be subject to additional terms and conditions of the advertiser. So, your actual offer terms from an advertiser may be different than the offer terms on this site. We strive to keep our information accurate and up-to-date, but some information may not be current. While we strive to provide a wide range of offers, our site does not include information about every product or service that may be available to you. The compensation we receive and other factors, such as your location, may impact what ads and links appear on our site, and how, where, and in what order ads and links appear. Many, but not all, of the offers and clickable hyperlinks (such as a “Next” button) that appear on this site are from companies that compensate us. To support our work, we are paid for providing advertising services. Our reporters create honest, accurate, and objective content to help you make decisions. ![]() The note should be given to the attendance office before 9:00AM. The note should include: student's name, student's ID number, reason for absence, the date, and phone number where the parent may be reached. When the student returns to school, he/she MUST present a written note from the parent even if a parent called the attendance line. 10 Facts about School Attendance High School Absenteeism and College Persistence. Students must sign in/out with the attendance office even if it is between passing periods.Ĭall the attendance line, (469) 752-7400, to report your student absent. Attendance Works Advancing Student Success by Reducing Chronic Absence. Upon returning to school, a note excusing the absence must be turned into the attendance office. Students must come to the attendance office to meet the parent who is signing them out. Approval from the attendance office is necessary before a teacher can allow a student to leave class. Our School Our Principal Our Staff Counselors Corner Counselors Corner. ![]() Public Participation at BOE Meeting - (Policy, Rules, Procedures, Form). The note should state the time the student will be picked up. Pickens County Schools in Jasper, Georgia. If a student must leave school during school hours, a note from the parent must be sent to the attendance office the morning of, so the student can get a pass to leave the classroom. How do I sign my student out for a doctor's appointment? Classes will not be interrupted for lunches or homework. There is a table in the vestibule right out side the office where items may be left for students to pick up during passing periods. Parents may drop off lunches, but they will not be delivered. Schedule changes only after the first three steps completed and issues persist. Two or three week trial period following parent/teacher conference.ĥ. Paperwork must be completed with the counselor.Ĥ. If an emergency arises, the student's parents or guardian should call the school, (41). If a student knows he/she must be absent because of an emergency, he/she should notify the school office as soon as possible. What is the procedure for changing a student's schedule?ģ. Someone designated, in writing or verbally, by one of the persons listed above. Students cannot drop a core class however, they can request a schedule change for a legitimate reason. Teresa has 2 jobs listed on their profile. The deadline for a level change, honors to regular, is the end of the first six weeks.Ĥ. View Teresa Browns profile on LinkedIn, the worlds largest professional community. How do you change from an Honors class to a regular class? Public 9-12 1501 Viking Drive Jasper, AL 35501-4999 (205) 221-9277 District: Jasper City SchoolDigger Rank: 91st of 367 Alabama High Schools Per Pupil Expenditures: 12,720 Feeder schools for Jasper High School: Student/teacher ratio: 17.0 Number of students: 748 Racial breakdown: White: 70.3 African American: 15.4 Hispanic: 11. Jasper High School Back to School Information Up close, the frit reveals a dense composition of layered, swooping curves, evocative of the motions of chefs’ hands at work. The familiarity and warmth of the burned finish juxtaposes the more contemporary fritted glass that wraps around the corner of the building. Flush at the corners where the eaves of the roof meet the siding, the kitchen’s streamlined body is partly clad in charred wood. The pitched, lowslung roofs of the kitchen and annex allude to their utilitarian function. The new architecture at The French Laundry is shaped by simple geometries that are both modern and reminiscent of agrarian architectural forms. The French Laundry has long been recognized for the culture of education and mentorship it provides its staff, and Snøhetta’s design not only optimizes efficiency but also fosters a meaningful environment for the chefs who work there, setting a stage for cuisine that ignites the senses. Through the rhythm, culture, pace, and precision of his work, Chef Keller cultivates an environment for his team to excel at creating one of the most esteemed kitchens in the world. To begin the design process, the designers spent time with Chef Keller’s team, observing the complex choreography of the kitchen. The design is the first major overhaul to the historic site in over two decades and doubles the size of the existing landscape for guests while providing a world-class working environment for Keller and his team to innovate their craft and service.Ī new kitchen annex houses the French Laundry’s support functions, including the butchery, produce breakdown, and wine collection, storing up to 15,000 bottles. ![]() ![]() Opened in 1994, Thomas Keller’s three-starred Michelin restaurant has been highly regarded as a mecca for fine French cuisine at the forefront of culinary culture over 20 years. Snøhetta, in collaboration with Chef Thomas Keller and Envelope A+D, has completed a new kitchen and courtyard renovation at The French Laundry in Yountville, California. ![]() Single threaded LZip has the best compression and uses far less than the multithread version, with a 1/cores speed ratio.Īs for the rest of the config dir, it is much more compressible and much smaller unless you have a bunch of media files in there or something: On systems with 2 or less cores, ZSTD-5 is probably the best option. 4 is a good chunk faster and uses even less memory, but the compression ratio takes a similar hit. Memory constrained systems should use single threaded LZip for best compression or ZSTD levels 4 through 9 for best speed. ZSTD level 9 will typically use half the compression memory of 10. I would use ZSTD-5 if you retain a single backup, have a small db, or want the shortest downtime between upgrades.įaster sysems with ample memory like this make better use of ZSTD-10įor mem requirements, PLZip and ZSTD-10 can use huge amounts of memory, over a gig in some cases. I would use PLZip if retaining lots of backups is important, or if you have larger databases. Level 17 is where size starts to drop, but at that point it is the same speed as PLZip but still not anywhere close to the compression ratio. I tested ZSTD level 15, but the compressed data size was within 1% of level 10 for this type of data, but at half the speed. I did not bother with gzip and lzop because of their poor compression ratio. LZip is also apparently a better format from a data recovery perspective. PLZip has the best combination of file size and speed, it is 4 times faster than XZ because it can use all 4 cores. PBZip retains compatibility with bz2 files, which means compatibility with pretty much any archiving software, even ancient ones. ZSTD will also have the fastest decompression time. So who wins? Depends on the need, ZSTD-10 is faster than it takes to pull the new docker image (if done in parallel, but 5 is obviously the fastest. Tar -c -I"zstd -5 -T0" -f -5 /var/homeassistant/home-assistant_v2.db Tar -c -I"zstd -10 -T0" -f -10 /var/homeassistant/home-assistant_v2.dbĮven faster but compression still not great: Super fast and similar compression to bzip Tar -c -Ipbzip2 -f 2 /var/homeassistant/home-assistant_v2.db ![]() High performance implementation compatible with regular bzip decompression ![]() High performance implementation compatible with regular lzip decompressionĤ times faster than XZ with almost the same compression ratio (both use LZMA) Tar -cJf /var/homeassistant/home-assistant_v2.db Native compression needing no external libs or compressors Files are read off a SATA SSD, processor is a 4-core 4-thread Haswell Xeon, files then are written to another SSD. So you need/want compression, I did a comparison of some methods, speed and size, on a 1GB db file. For those of you using Docker with the standard DB (or even a non-docker install), who want to back up their config prior to pulling a new release, you may also want to backup your DB file, even if it is large. |
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